2021年4月5日 星期一

住院醫師的身體檢查範本(完整版)

l   Vital signsBP:162/ 108 mmHg, BT:37 °C, PR:100 /min, RR:18 /min, SpO2:100 %, Pain score: 0/10                 

l   Generalchronic ill-looking | (Description of findings)

l   Consciousness

-          alert and clear (to person, time and place. GCS: E4M6V5 

l   HEENT (head, eyes, ears, nose, and throat)

-          no head deformity,

-          pink conjunctivae, anicteric sclera

-          isocoric pupil (R/L): 3mm/3mm, prompt light reflex (R/L): positive/positive

-          ear: normal appearance

-          throat: no injection, no ulcers, no pus

l   NECK

-          supple, no Brudzinski's sign, no Kernig's sign,

-          no carotid bruit

-          normal estimate CVP (< 3+5cm), no jugular vein engorgement, no absent A wave (AF), no giant A wave (TS, PHT), no cannon A wave (AV dissociation), no large V wave (TR), no slowly Y wave (TS), no hepato-jugular reflux (HF), no Kussmal's sign (Constrictive pericarditis, HF)

-          no palpable lymph nodes, no palpable thyroid gland

-          no difficult airway (3-3-2)

l   CHEST

-          Inspection: symmetric expansion, no visible chest deformity, no scar, no use of accessory respiratory muscle, no spider angiomata

-          Palpation: no increased tactil fremitus 

-          Percussion: bilateral resonant, no hyperresonance, no dullness, normal cardiac silhouette on percussion                

-          Auscultation: bilateral symmetric clear breath sound, no crackles, no wheezing, no rhonchi, no rales, no bronchophony, no egophony

l   HEART:                                   

-          Inspection: no visible PMI, parasternal lift, dyskinesis and aneurysm

-          Palpation: PMI over left 4th intercostal space and medial to the mid-clavicular line, no RV heave (volume load / pressure load), no left 2nd interspace lift (pulmonary: PHT), no right 2nd interspace lift (aortic: HTN), no epigastric area lift (RV in hyperinflated lungs), no thrills (Gr. 4+ murmurs) over 4 vulvular area, no ectopic heave or thrill

-          Percussion: normal cardiac silhouette on percussion            

-          Auscultation: regular heart beat, normal S1 and S2, no S1 decreasement, no pathological S2 splitting, no S3, no S4, no gallop, no audible murmur no extra systolic/diastolic sounds (Ejection sound (AS), Mid-systolic click (MVP), Opening snap (MS, TS)), no audible murmurs / abnormal heart sounds on squatting, valsalva / standing, inspiration maneuvers

l   ABDOMEN:                                  

-          Inspection: flat, no scar, no umbilical hernia, no engorged superficial vein, no caput medusae, no Cullen's sign, no Grey-Turner's sign

-          Auscultation: normoactive bowel sound, no bruits

-          Palpation: soft, no tenderness, no muscle guarding, no rebound tenderness, no Murphy`s sign, no McBurney's point tenderness, no Psoas' sign, no Obturator's sign, impalpable liver and spleen, no palpable mass

-          Percussion: no tympany, no shifting dullness, no percussion wave, no succussion splash,                  

-          liver span: normal span at right mid-clavicular line

l   BACK

-          no CV angles knocking tenderness

-          no kyphosis, no scoliosis

-          negative straight leg raising test

l   EXTREMITIES

-          freely movable, no deformity, no peripheral cyanosis, no clubbing finger, no palmar erythema, no pitting edema

-          radial pulsation: normal pulse rate, regular rhythm, no pulsus alternans(HF), no pulsus parvus et tardus (AS), no pulsus paradoxus (Pericardial tamponade, Constric pericarditis), no pulsus bisferiens (HOCUM), nobounding pulse (Chronic AR), no bigeninal (Premature beats), no dicrotic (Cardiomegaly), no filiform (Shock)                    

l   LYMPH NODES:                                

-          no neck, no axillary, no epitrochlear, no inguinal, no popliteal LAP

l   DIGITAL RECTAL EXAMINATION:                         

-          no skin tag, no visible hemorroid, no anal fissure, no perianal abscess, no anal fistula, tight anal tone, smooth rectal wall, no induration, no rectal shelf, no tenderness

-          brownish color stool over glove   

-          prostate (indicated in male patient): egg-sized, no enlargement, elastic character, normal sulcus, no palpable mass, no tenderness   

l   Integument: normal skin turgor, no cyanosis, no skin rash           


2021年3月2日 星期二

肝癌的血清腫瘤指標

Serum markers of hepatocellular carcinoma (HCC) 

※※ 今天跟老師討論病人發現有PIVKA-II這個marker,所以整理一下。


甲型胎兒蛋白 (Alpha-fetoprotein, AFP)

  • 最常用的血清指標,妊娠時期胎兒的肝臟和卵黃囊產生的一種醣蛋白,但是部分HCC會分泌,故可以拿來使用。
  • 正常值:< 20 ng/ml
  • 半衰期:5-7天
  • 診斷HCC:sensitivity ~60%、specificity ~80%
    • 濃度越高,specificity會越高、但是sensitivity會越低:例如本身是HCC高風險的人,今天若AFP>400ng/ml,診斷HCC的specificity 會 >95%;但是臨床上不到1/5的病人會高過400ng/ml
  • 其他AFP會升高卻不是HCC的狀況:
    • 慢性肝炎:acute or chronic viral hepatitis
      • 一篇研究收錄 357 chronic or acute HCV的病人 => 23% 病人 AFP >10 ng/mL, AFP範圍0.3 ~ 241 ng/mL,AFP上升和第三四期的肝纖維化stage 3 or 4 fibrosis、INR延長者、AST/ALT上升者有關
        Am J Gastroenterol. 2004;99(5):860. 
    • 懷孕婦女
    • 性腺來源的腫瘤(包括生殖細胞、非生殖細胞)、多種惡性腫瘤尤其是胃癌

  • 臨床角色和應用:
    • 隨著影像學的進步,已經不再是診斷上的標準,從很多臨床上的指引拿掉了;如果HCC診斷之初濃度有高,可以當作後續追蹤治療反應或是惡化之用。
    • 肝臟移植捐贈者評估,如果AFP level >1000 ng/mL可能排除之(standardized MELD exception)
    • AFP濃度通常在晚期肝細胞癌比早期肝細胞癌要高,但是濃度高低和臨床表現嚴重度沒有很好的相關。

維生素K缺乏或拮抗劑-II誘導的蛋白質
(Protein Induced by Vitamin K Absence or Antagonist-II, PIVKA-II)(des-gamma-carboxy prothrombin, DCP)

  • 在Vit-K或是HCC導致的凝血功能異常,會產生一種異常的凝血酶原,叫做PIVKA-II或DCP,正常人體內不會有
  • 正常值:台大抓 10~31 ng/ml
  • 半衰期:40-72小時
  • 診斷原發性HCC:sensitivity ~60%、specificity ~80%
  • 臨床角色和應用:
    (Yu et al. BMC Cancer (2017) 17:608 DOI 10.1186/s12885-017-3609-6)
    • Vit-K沒有缺乏下,如果PIVKA-II上升,要懷疑有肝病或HCC
    • 由PIVKA-II診斷的 1016 位HCC患者
      • 88.7% 是原發性肝癌,其中6成左右是晚期肝癌
      • PIVKA-II在晚期肝癌濃度比較高(平均4650.0 mAU/ml, 範圍667.0–33,438.0 mAU/ml) ,相比早期肝癌濃度 (平均104.5 mAU/ml, 範圍61.0–348.8 mAU/ml),兩者 P < 0.001
      • 12.3%是復發性肝癌,在復發組濃度比進步組高(P < 0.001)
      • 但注意還是有 1054 PIVKA-II 陽性卻沒有HCC
        • cirrhosis (46.3%), hepatitis (20.6%), benign nodules (15.3%).
    • 在高風險者若是濃度上升,兩年內會發展成HCC
    • 目前會建議合併PIVKA-II和AFP來診斷原發性肝癌,Sensitivity高於單獨使用PIVKA-II或AFP,但specificity並無顯著差異。
  • 自費費用:$1200~1500
  • 健保適應症:
    • 1.肝硬化之慢性肝炎(含酒精性肝硬化),並符合下列條件之一:
      • (1)肝組織切片Metavir F4或Ishak F5以上,另血友病病人及類血友病病人經照會消化系專科醫師同意後,得不作切片。
      • (2)超音波診斷為肝硬化併食道或胃靜脈曲張,或肝硬化併脾腫大
      • (3)電腦斷層或磁振造影檢查診斷為肝硬化
    • 2.肝癌接受根除治療之病人
    • 使用健保碼執行頻率:每年兩次
    • 依據健保署2020-06-30公告(健保醫字第1090033536號)

Lens culinaris agglutinin-reactive AFP (AFP-L3) 

  • 後續發現AFP和凝集素 LCA (Lens culinaris agglutinin)的親合力不同,可以將其分出L1、L2、L3,L1和LCA親合力最弱,產生於慢性肝炎和肝硬化的的肝臟;L2和LCA親合力次之,多和生殖細胞腫瘤和懷孕有關;L3和LCA結合力最好,和HCC有關。
  • 診斷HCC : sen 56%, spe >95%
  • 臨床應用:

Glypican-3 (GPC3)

  • 一種細胞膜上的硫酸肝素蛋白多醣(heparan sulfate proteoglycan, HSPG)
  • highly expressed in hepatocellular carcinoma (HCC)
  • 臨床應用:目前多為研究治療相關的target之一


未來有淺在機會的指標

血漿小RNA片段 (microRNAs)

  • MicroRNA panel:  miR-122, miR-192, miR-21, miR-223, miR-26a, and miR-801 可以準確地偵測有各stage HCC的病人
  • 準確的區分HCC患者、健康人、慢性B肝、肝硬化
  • 臨床運用:study

Ref:

  1. 師長所述
  2. Yu et al. BMC Cancer (2017) 17:608 DOI 10.1186/s12885-017-3609-6.  Effectiveness of PIVKA-II in the detection of hepatocellular carcinoma based on real-world clinical data.
  3.  
    Clinical features and diagnosis of hepatocellular carcinoma

#HCC #Tumor marker #PIVAK-II #AFP